血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

doi:10.3969/j.issn.1006-7795.2015.02.022

首都医科大学学报 ›› 2015, Vol. 36 ›› Issue (2): 287-290.doi: 10.3969/j.issn.1006-7795.2015.02.022

血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

高新晓¹, 郭佳¹, 蔺洁², 孟忻¹, 汪军¹

1. 首都医科大学附属北京安贞医院眼科, 北京 10029;
2. 首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所动脉粥样硬化研究室, 北京 10029

收稿日期:2014-12-15 发布日期:2015-04-16
通讯作者: 汪军 E-mail:junmaster@live.cn
基金资助:
国家自然科学基金(81370443,81170793),中华医学会临床医学科研专项资金项目(14010110548),首都医科大学附属北京安贞医院院长科技发展基金种子基金(2013Z02)。

Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

Gao Xinxiao¹, Guo Jia¹, Lin Jie², Meng Xin¹, Wang Jun¹

1. Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China;
2. The Key Laboratory of Remodeling-related Cardiovascular Diseases, Ministry of Education, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing 100029, China

Received:2014-12-15 Published:2015-04-16
Supported by:
This study was supported by National Natural Sciences Foundation of China(81370443, 81170793), Clinical Research Foundation from Chinese Medical Association(14010110548), Seed Project of Technical Development Foundation from Capital Medical University Affiliated Beijing Anzhen Hospital(2013Z02).

摘要/Abstract

摘要：

目的精确检测低密度脂蛋白(low density lipoprotein,LDL)的亚组分并评估其中的小而密低密度脂蛋白(small dense LDL,sdLDL)与青年角膜弓(简称青年弓)的相关性。方法入选12例2014年3月至2014年10月就诊于首都医科大学附属北京安贞医院眼科及体检中心的血脂正常的青年弓患者。另外选取12例年龄、性别、吸烟史相匹配的健康对照者。采用Lipoprint LDL System精确检测LDL的亚组分,计算其中的sdLDL占LDL的百分数,即sdLDL比率(sdLDL%)。采用t检验比较青年弓组与对照组的sdLDL%,再以青年弓为因变量,通过Logistic回归分析(Backward:LR)评估其相关因素。结果与对照组相比,青年弓组sdLDL%数值偏高[(13.16±6.29)% vs (19.64±6.52)%],差异有统计学意义(P=0.020)。Logistic回归分析显示:将年龄、LDL校正后,sdLDL%增高和青年弓明显相关(P=0.040)。sdLDL%是青年弓发生的危险因素(OR=1.49,95% CI:1.01~2.19,P<0.05)。结论血脂正常青年弓患者的sdLDL%增高,表明其LDL亚组分异常。

关键词: 青年角膜弓, Lipoprint LDL System, 小而密低密度脂蛋白

Abstract:

Objective To exactly analyze low density lipoprotein(LDL) subclass and examine the association between small dense LDL(sdLDL) and corneal arcus in young patients. Methods We selected 12 cases of young patients with corneal arcus and normal serum lipids. Another 12 control cases with matched age, gender, smoking were recruited from Beijing Anzhen Hospital between March 2014 and October 2014. LDL particle separation was performed by Lipoprint System: LDL subfractions were obtained and sdLDL proportion(% of sdLDL particles) was calculated. sdLDL% was compared with the Student t test between two groups. Logistic regression analysis was performed to evaluate the correlation between corneal arcus and its related factors. Results SdLDL% was increased in corneal arcus group compared with controls[(19.64±6.52)% vs (13.16±6.29)%]. The difference between the two groups was significant(P=0.020). SdLDL% was significantly associated with corneal arcus(P=0.040) after controlling for age and LDL. SdLDL% played a role in the development of corneal arcus(OR=1.49, 95% CI: 1.01-2.19, P<0.05). Conclusion These findings suggested that young patients with corneal arcus and normal serum lipids had increased level of sdLDL proportion, indicating the abnormality of LDL subclass in such cases.

Key words: corneal arcus, Lipoprint LDL System, small dense low density lipoprotein

中图分类号:

R446

高新晓, 郭佳, 蔺洁, 孟忻, 汪军. 血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析[J]. 首都医科大学学报, 2015, 36(2): 287-290.

Gao Xinxiao, Guo Jia, Lin Jie, Meng Xin, Wang Jun. Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids[J]. Journal of Capital Medical University, 2015, 36(2): 287-290.

参考文献

[1] Christoffersen M, Frikke-Schmidt R, Schnohr P, et al. Xanthelasmata, arcus corneae, and ischaemic vascular disease and death in general population:prospective cohort study[J]. BMJ, 2011,343:d5497.
[2] Wu R, Wang J J, Tai E S, et al. Cardiovascular risk factors, inflammation, and corneal arcus:the singapore malay eye study[J]. Am J Ophthalmol, 2010,150(4):581-587.
[3] Crispin S. Ocular lipid deposition and hyperlipoproteinaemia[J]. Prog Retin Eye Res, 2002,21(2):169-224.
[4] Newell F W. The Cornea[M]. 8th ed. St. Louis:CV Mosby Co., 1986.
[5] Austin M A, Breslow J L, Hennekens C H, et al. Low-density lipoprotein subclass patterns and risk of myocardial infarction[J]. JAMA, 1988,260(13):1917-1921.
[6] Chapman M J, Guérin M, Bruckert E. Atherogenic, dense low-density lipoproteins. Pathophysiology and new therapeutic approaches[J]. Eur Heart J, 1998,19(Suppl A):A24-A30.
[7] Berneis K K, Krauss R M. Metabolic origins and clinical significance of LDL heterogeneity[J]. J Lipid Res, 2002,43(9):1363-1379.
[8] Moon J Y, Kwon H M, Kwon S W, et al. Lipoprotein(a) and LDL particle size are related to the severity of coronary artery disease[J]. Cardiology, 2007,108(4):282-289.
[9] Kullo I J, Ballantyne C M. Conditional risk factors for atherosclerosis[J]. Mayo Clin Proc, 2005,80(2):219-230.
[10] Pauciullo P, Gentile M, Marotta G, et al. Small dense low-density lipoprotein in familial combined hyperlipidemia:independent of metabolic syndrome and related to history of cardiovascular events[J]. Atherosclerosis, 2009,203(1):320-324.
[11] Lagos K G, Filippatos T D, Tsimihodimos V, et al. Alteration in the high density lipoprotein phenotype and HDL associated enzymes in subjects with metabolic syndrome[J]. Lipids, 2009,44(1):9-16.
[12] Mora S, Otvos J D, Rosenson R S, et al. Lipoprotein particle size and concentration by nuclear magnetic resonance and incident type 2 diabetes in women[J]. Diabetes, 2010,59(5):1153-1160.
[13] Fernández A, Sorokin A, Thompson PD. Corneal arcus as coronary artery disease risk factor[J]. Atherosclerosis, 2007,193(2):235-240.
[14] 孟忻,蔺洁,辛晨,等.杂合型家族性高胆固醇血症的角膜青年环一例[J].眼科,2012,21(2):105-106.
[15] Meng X, Lin J, Gao X, et al. Corneal arcus and xanthomas in homozygous familial hypercholesterolemia:first report from China[J]. Indian J Ophthalmol, 2013;61(12):770-771.
[16] Krauss R M. Dense low density lipoproteins and coronary artery disease[J]. Am J Cardiol, 1995,75(6):53B-57B.
[17] Fernandez A B, Keyes M J, Pencina M, et al. Relation of corneal arcus to cardiovascular disease[J]. Am J Cardiol, 2009,103(1):64-66.
[18] Zech L A Jr, Hoeg J M. Correlating corneal arcus with atherosclerosis in familial hypercholesterolemia[J]. Lipids Health Dis, 2008,7:7.
[19] Ang M, Wong W, Park J, et al. Corneal arcus is a sign of cardiovascular disease, even in low-risk persons[J]. Am J Ophthalmol, 2011,152(5):864-871.

血脂正常青年角膜弓患者的低密度脂蛋白亚组分分析

Analysis of low density lipoprotein subclass in young patients with corneal arcus and normal serum lipids

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	李榕, 陈静, 李传云, 周童, 陈欢, 陈德喜, 乔跃兵, 李伟华. 过滤对超速离心法提取外泌体的影响[J]. 首都医科大学学报, 2021, 42(6): 1007-1013.
[2]	尉景娟, 马立艳, 苏建荣. 替加环素与5种抗菌药物对耐左氧氟沙星嗜麦芽窄食单胞菌的体外药敏试验及联合药敏试验[J]. 首都医科大学学报, 2021, 42(4): 623-628.
[3]	李雪, 石中月, 杨志明, 庞文博, 金木兰. 人工智能辅助分析在宫颈液基薄层细胞学检查中的应用价值[J]. 首都医科大学学报, 2020, 41(3): 360-363.
[4]	梅曼, 任添华. 静脉血和动脉血气电解质、血红蛋白浓度的相关性研究[J]. 首都医科大学学报, 2020, 41(2): 267-271.
[5]	乔莉, 曹洋, 袁宏勋, 王瑶. ICU中心静脉导管相关性血流感染的危险因素及病原菌分析[J]. 首都医科大学学报, 2020, 41(1): 125-130.
[6]	王蕤, 吴素萍, 徐品颖. 血浆miRNA-320C和miRNA-6088对Ⅱ型糖尿病肾病的诊断价值[J]. 首都医科大学学报, 2019, 40(3): 466-472.
[7]	李东, 张树琛, 时琰丽, 李雪清, 鲁炳怀. 北京地区孕晚期妇女定植B族链球菌耐药状况与血清型分布情况分析[J]. 首都医科大学学报, 2018, 39(4): 591-595.
[8]	刘竞争, 郑光辉, 吕虹, 陈燕, 马瑞敏, 张国军. “ESKAPE”在神经外科医源性感染的流行病学研究[J]. 首都医科大学学报, 2017, 38(4): 530-534.
[9]	白晶, 张立军, 展玉涛, 郭多, 刘向祎. 化学发光酶免疫法检测血清GP73的临床应用[J]. 首都医科大学学报, 2017, 38(4): 566-571.
[10]	张树琛, 王杉, 朱凤霞, 时琰丽, 李东, 鲁炳怀. B群链球菌显色培养基在孕产妇B群链球菌筛查中的性能评价[J]. 首都医科大学学报, 2016, 37(5): 680-683.
[11]	杨品娜, 刘刚, 田敬华. 煤工尘肺合并慢性阻塞性肺疾病患者痰培养细菌耐药情况分析[J]. 首都医科大学学报, 2016, 37(4): 486-490.
[12]	吕虹, 吴渊, 王利娟, 张国军. 抗神经元抗体对神经系统副肿瘤综合征诊断的意义[J]. 首都医科大学学报, 2016, 37(4): 491-494.
[13]	方芳, 陈柯霖, 陈燕, 黄泽玉, 吕虹, 刘淑静, 周金, 张国军, 康熙雄. 应用CNAS CL-36标准评估HBV DNA定量检测试剂的抗干扰能力[J]. 首都医科大学学报, 2016, 37(4): 495-499.
[14]	刘相佟, 陶丽新, 杨昆, 李海彬, 郭晋, 郭秀花. 血红蛋白与成人代谢综合征及其组分关联性的五年队列研究[J]. 首都医科大学学报, 2016, 37(4): 509-512.
[15]	王克迪, 苏建荣. 化学发光微粒子免疫检测法筛查梅毒的结果分析[J]. 首都医科大学学报, 2016, 37(4): 519-522.