代谢综合征与相应血常规指标的关联性研究

doi:10.3969/j.issn.1006-7795.2016.02.018

首都医科大学学报 ›› 2016, Vol. 37 ›› Issue (2): 203-207.doi: 10.3969/j.issn.1006-7795.2016.02.018

代谢综合征与相应血常规指标的关联性研究

杨昆^1,2, 陶丽新^1,2, 曹凯^1,2, 刘相佟^1,2, 李海彬^1,2, 闫傲霜³, 郭秀花^1,2

1. 首都医科大学公共卫生学院流行病与卫生统计学系, 北京 100069;
2. 北京市临床流行病学重点实验室, 北京 100069;
3. 北京市科学技术委员会, 北京 100195

收稿日期:2015-10-21 出版日期:2016-04-21 发布日期:2016-04-14
通讯作者: 闫傲霜 E-mail:guoxiuh@ccmu.edu.cn
基金资助:
国家自然科学基金(81070319),北京市自然科学基金(710201),北京市中医药科技发展资金(JJ2013-02)

Relationships between metabolic syndrome and its related blood indexes

Yang Kun^1,2, Tao Lixin^1,2, Cao Kai^1,2, Liu Xiangtong^1,2, Li Haibin^1,2, Yan Aoshuang³, Guo Xiuhua^1,2

1. Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing 100069, China;
2. Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing 100069, China;
3. Beijing Municipal Science and Technology Commission, Beijing 100195, China

Received:2015-10-21 Online:2016-04-21 Published:2016-04-14
Supported by:
This study was supported by National Natural Science Foundation of China (81070319), Natural Science Foundation of Beijing (7102013), Beijing Traditional Chinese Research Program (JJ2013-02).

摘要/Abstract

摘要： 目的探讨北京市成年人群代谢综合征(metabolic syndrome,MetS)的发生与血常规指标的关联性。方法选取来自北京3所医院的体检者作为研究对象,调查并追踪记录男女人群血常规指标及MetS各组分的检出情况,采用广义估计方程探讨代谢综合征的发生与血常规指标的关联性。结果 2007至2012年间参加3次以上体检并符合研究要求的对象共7 489人,共有378人发生MetS。与MetS发生相关联的血常规指标,以最低的四分位数作参照,对男性而言,红细胞比容(hematocrit value, HCT)和白细胞计数(white blood cell, WBC) 的第四分位发生MetS的RR值分别为1.861 3(95%CI:1.325 6~2.613 5)和 2.598 4(95%CI:1.805 5~3.739 5);对女性而言,红细胞计数(red blood cell, RBC)、WBC和淋巴细胞的第四分位发生MetS的RR值分别为3.146 3(95%CI:1.836 3~5.391 0)、1.897 1(95%CI:1.089 9~3.302 2)和2.200 8(95%CI:1.221 9~3.964 0)。结论北京市成年人群体检中HCT、WBC、RBC和淋巴细胞等血常规指标与MetS的发生具有关联性,可作为MetS发生的预测指标。

关键词: 代谢综合征, 血常规指标, 广义估计方程, 队列研究

Abstract: Objective To evaluate the relationships between metabolic syndromes (MetS) and its related blood indexes in Beijing adults' population.Methods Subjects from Beijing three hospitals were enrolled and blood indexes record were tracked. The detection rates of MetS and its accompanying blood indexes were investigated. Generalized estimation equation model was used to estimate the relationships between MetS and its related blood indexes. Results 7 489 subjects, who attended the health check-up from 2007 to 2012, were incorporated into the final analysis. During the 5 year follow-up, 378 cases of MetS were developed. The related blood routine indexes with MetS were hematocrit value (HCT) and white blood cell (WBC) for males. Compared with Q1, the lower quartile of HCT and WBC, the RRs of Q4 were 1.861 3 (95% CI: 1.325 6-2.613 5) and 2.598 4(95% CI: 1.805 5-3.739-5), respectively. Red blood cell (RBC), WBC and lymphocyte were corresponding factors for females. Compared with Q1, the lower quartile of RBC, WBC and lymphocyte, the RRs were 3.146 3 (95% CI: 1.836 3-5.391 0), 1.897 1 (95% CI: 1.089 9-3.302 2) and 2.200 8 (95% CI: 1.221 9-3.964 0), respectively.Conclusion MetS has a certain association with its related blood routine parameters, such as HCT, WBC, RBC and Lymphocyte applied by health check-up data in Beijing adults, and such parameters may be used as the predictors of MetS.

Key words: metabolic syndrome, blood routine parameters, generalized estimation equation, longitudinal cohort study

中图分类号:

R589

杨昆, 陶丽新, 曹凯, 刘相佟, 李海彬, 闫傲霜, 郭秀花. 代谢综合征与相应血常规指标的关联性研究[J]. 首都医科大学学报, 2016, 37(2): 203-207.

Yang Kun, Tao Lixin, Cao Kai, Liu Xiangtong, Li Haibin, Yan Aoshuang, Guo Xiuhua. Relationships between metabolic syndrome and its related blood indexes[J]. Journal of Capital Medical University, 2016, 37(2): 203-207.

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代谢综合征与相应血常规指标的关联性研究

Relationships between metabolic syndrome and its related blood indexes

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