Age-related changes of upper limb performance time and its association with the uptake ratio of 99mTc-TRODAT-1 in normal cynomolgus monkeys

doi:10.3969/j.issn.1006-7795.2011.06.016

Journal of Capital Medical University ›› 2011, Vol. 32 ›› Issue (6): 787-792.doi: 10.3969/j.issn.1006-7795.2011.06.016

• 帕金森病的发病机制研究 • Previous Articles Next Articles

Age-related changes of upper limb performance time and its association with the uptake ratio of ^99mTc-TRODAT-1 in normal cynomolgus monkeys

YUE Feng¹, WU Di², ZENG Si-en³, YI De-qiao⁴, ZHANG Yu², CHEN Biao¹

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University;Key Laboratory of Neurodegenerative Diseases,Ministry of Education, Beijing 100053,China;2. Cell Therapy Center, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;3. Department of Pathology, Guilin Medical College, Guilin 541004,China;4. Wincon TheraCells Biotechnologies Co. Ltd., Nanning 530000, China

Received:2011-10-16 Revised:1900-01-01 Online:2011-12-21 Published:2011-12-21

Abstract

Abstract: Objective The present study investigates age-related changes of upper limb performance time and its correlation with the aging-associated alterations of uptake ratio of ^99mTc-TRODAT-1. Methods A total of 30 cynomolgus monkeys ranging from 3.5 to 15.5 years old were studied. The upper limb performance was quantitatively assessed using a modified movement assessment panel(MAP), and the function of the dopaminergic system represented by striatal dopamine transporter(DAT) uptake ratio was semi-quantatively detected using ^99mTc-TRODAT-1 single-photon emission computed tomography(SPECT) imaging. Results A significant slowness of upper limb performance time was associated with aging and significantly correlated with age-related decrease in ^99mTc-TRODAT-1 uptake ratio. A further partial correlational analysis independent of age indicates that aging is inclined to drive the relationship between striatal DAT levels and upper limb performance time. Conclusion Our results suggest that aging-associated dysfunction of dopaminergic function is at least an important factor underlying the age-related slowness of upper limb performance time in normal cynomolgus monkeys.

Key words: motor behavior, dopamine, ^99mTc-TRODAT-1, aging, single photon emission computed tomography, primates

CLC Number:

R 592

YUE Feng;WU Di;ZENG Si-en;YI De-qiao;ZHANG Yu;CHEN Biao. Age-related changes of upper limb performance time and its association with the uptake ratio of ^99mTc-TRODAT-1 in normal cynomolgus monkeys[J]. Journal of Capital Medical University, 2011, 32(6): 787-792.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2011.06.016

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2011/V32/I6/787

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Age-related changes of upper limb performance time and its association with the uptake ratio of ^99mTc-TRODAT-1 in normal cynomolgus monkeys

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