Immunolocalization of α-synuclein in human meningiomas tissues

doi:10.3969/j.issn.1006-7795.2011.06.017

Journal of Capital Medical University ›› 2011, Vol. 32 ›› Issue (6): 793-797.doi: 10.3969/j.issn.1006-7795.2011.06.017

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Immunolocalization of α-synuclein in human meningiomas tissues

WU Yang¹, SU Yu-jin², LI Xin¹, LIU Guang-wei¹, LI Yao-hua¹, YU Shun¹

1. Department of Neurobiology, Xuanwu Hospital, Capital Medical University;Beijing Geriatric Medical Research Center;Key Laboratory of Neurodegenerative Diseases, Ministry of Education, Beijing 100053, China;2. Institute of Neuroscience, Tiantan Hospital, Capital Medical University, Beijing 100050, China

Received:2011-10-16 Revised:1900-01-01 Online:2011-12-21 Published:2011-12-21

Abstract

Abstract: Objective To investigate the localization of α-synuclein(α-syn) in human brain meningiomas tissues and its association with β-tubulin. Methods Immuohistochemistry with antibodies against α-syn was used to reveal the localizations of α-syn in normal brain and meningiomas tissues. Double immunofluorescent labeling was used to observe the co-localization of α-syn with β-tubulin. Results In normal brain tissues, α-syn was localized in presynaptic terminals and cytoplasms of the neuronal somata, which was co-localized with synaptophysin and β-tubulin, respectively. In meningiomas tissues, α-syn was observed in cytoplasms and nuclei of the tumor cells. α-Syn in tumor cells were found to be co-localized with β-tubulin. Conclusion α-Syn was localized in the cytoplasm and nucleus of the meningiomas cells, and colocalized with β-tubulin.

Key words: α-synuclein, β-tubulin, meningiomas

CLC Number:

R 338

WU Yang;SU Yu-jin;LI Xin;LIU Guang-wei;LI Yao-hua;YU Shun. Immunolocalization of α-synuclein in human meningiomas tissues[J]. Journal of Capital Medical University, 2011, 32(6): 793-797.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2011.06.017

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2011/V32/I6/793

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Immunolocalization of α-synuclein in human meningiomas tissues

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