Protective effect of insulin on delayed neuropsychologic sequelae after carbon monoxide poisoning in the rat and its mechanisms

doi:10.3969/j.issn.1006-7795.2012.02.020

Abstract

Abstract: Objective To determine the effects of insulin on cognitive function and neuronal apoptosis in delayed encephalopathy rat model of carbon monoxide(CO) poisoning. Methods The rat carbon monoxide poisoning model was established with introducing CO into abdominal cavity. Rats were randomly divided into two groups: CO group and RI-treated group , simultaneously administered 2 g/kg of glucose and 2 U/kg of regular insulin(RI) by intraperitoneal injection for 7 days. The learning and memory in delayed encephalopathy rat model of carbon monoxide poisoning were studied by using a Morris water maze from 1~5 weeks. At 5 weeks after CO exposure brains were perfusion-fixed. Neuronal changes were detected by thionine stain, TUNEL stain was used to assess injury. The data were expressed as(x±s ) and analyzed by analysis of variance. A P value less than 0.05 indicated significance. Results The cognitive function and neuronal apoptosis of RI-treated-group were improved as compared with CO group. Conclusion Insulin could inhibit the cell apoptosis and improve the cognitive function. Insulin could protect the nerve functions and alleviate on delayed neuropsychologic sequelae(DNS) after carbon monoxide poisoning.

Key words: carbon monoxide poisoning, delayed neuropsychologic sequelae, neural apoptosis, insulin

CLC Number:

R 749.6+3

LIAO Qiu-ju;WANG Jing;QIN Jian . Protective effect of insulin on delayed neuropsychologic sequelae after carbon monoxide poisoning in the rat and its mechanisms[J]. Journal of Capital Medical University, 2012, 33(2): 233-237.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2012.02.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2012/V33/I2/233

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Protective effect of insulin on delayed neuropsychologic sequelae after carbon monoxide poisoning in the rat and its mechanisms

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