Change of NHERF family protein and CAL protein in Parkinson’s rats gastrointestinal tissue

doi:10.3969/j.issn.1006-7795.2013.02.014

Abstract

Abstract:

Objective To study the expression of NHERF family protein and CAL protein in the digestive system of Parkinson’s disease, and investigate the mechanism of the dysfunction of digestive system in Parkinson’s disease. Methods Substantia nigra dopaminergic neurons of the SD rats were damaged by injecting 6-hydroxydopamine(6-OHDA) in the brain substantia nigra. Western blotting analysis for the expression of NHERF family protein and CAL protein in the gastry, duodenum and colon of the control and 6-OHDA treated rats were performed. Results The Western blotting results showed that the protein level of PDZK1 and CAL in the gastric corpus was enhanced in 6-OHDA treated rats, the protein level of NHERF1, NHERF2 and PDZK1 in the duodenum was increased in 6-OHDA treated rats, the protein level of NHERF1, PDZK1 and CAL in the colon was enhanced in 6-OHDA treated rats. Conclusion The upregulation of NHERF family protein and CAL protein may contribute to the dysfunction of digestive system in 6-OHDA treated rats. These results provide a strong evidence for further studying the mechanisms of digestive system dysfunction in Parkinson’s disease.

Key words: NHERF family protein, CAL, 6-OHDA treated rats, gastry, duodenum, colon

CLC Number:

R392.11

SHI Xiaocui, FENG Xiaoyan, SONG Ran, YANG Longyan, HE Junqi. Change of NHERF family protein and CAL protein in Parkinson’s rats gastrointestinal tissue[J]. Journal of Capital Medical University, 2013, 34(2): 232-238.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.02.014

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I2/232

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