Progress of the preconditioning mechanism on ischemia-reperfusion injury and its application prospect

doi:10.3969/j.issn.1006-7795.2013.06.026

Abstract

Abstract:

Ischemic disease is a common pathophysiological phenomenon which might cause serious complications when occurred in the vital organs such as heart and brain. Reperfusion can significantly reduce infarct size, but may result in ischemia-reperfusion injury at the same time. Numerous studies have shown that preconditioning is a powerful intervention to alleviate ischemia/reperfusion injury.The mechanisms include suppression of oxidative stress response, inhibition of reactive oxygen species(ROS) and nitric oxide(NO) release, reduction of intracellular calcium overload, activation of mitochondrial ATP-sensitive potassium chanels,and decreasing inflammation response. In this paper, the preventive effect and mechanism of preconditioning on ischemia/reperfusion injury were reviewed.

Key words: ischemia/reperfusion injury, preconditioning, oxidative stress, intracellular calcium overload, inflammation response

CLC Number:

R743.31

WANG Shanshan, HAN Ruquan. Progress of the preconditioning mechanism on ischemia-reperfusion injury and its application prospect[J]. Journal of Capital Medical University, 2013, 34(6): 910-914.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.026

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/910

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