Analysis of T cell activation in early HIV-infected individuals from MSM population

doi:10.3969/j.issn.1006-7795.2014.01.020

Abstract

Abstract:

Objective To evaluate the immune activation of T cells in early human immunodeficiency virus (HIV)-infected individuals, to find out the predictors for disease progression of early HIV-infected individuals. Methods Twenty-five early HIV-infected individuals, screened from the cohort of men who have sex with men (MSM) of Beijing YouAn Hospital were enrolled in this study. Frozen peripheral blood mononuclear cells (PBMCs) from early HIV-infected and uninfected individuals were obtained. The expression of activation markers CD38 and human leukocyte antigen DR (HLA-DR) on T cells were detected by flow cytometry. Correlations between T cell activation and CD4 T cell count or plasma viral load in early HIV-infected individuals were analyzed by Pearson test.Results Compared with uninfected individuals, the frequencies of HLA-DR⁺CD4⁺T cells and CD38⁺HLA-DR⁺CD4⁺T cells were significantly increased in early HIV-infected individuals (P<0.05), but no significant difference in the frequency of HLA-DR⁺CD4⁺T cells was observed. Moreover, the frequencies of CD38⁺CD8⁺T cells, HLA-DR⁺CD8⁺T cells and CD38⁺HLA-DR+CD8⁺T cells were significantly elevated in early HIV-infected individuals compared to uninfected individuals(P<0.05). However, no significant differences in CD38 and HLA-DR expression on T cell were observed between early HIV-infected individuals with different infection time. Furthermore, the frequencies of CD38⁺ CD8⁺T cells and CD38⁺HLA-DR+CD8⁺T cells were negatively correlated with CD4 cell count, and positively correlated with plasma viral load. Conclusion The frequencies of CD38⁺ CD8⁺T cells and CD38⁺HLA-DR+CD8⁺T cells may be used as the predictor for disease progression in early HIV-infected individuals.

Key words: men who have sex with men, T cells, human immunodeficiency virus, immune activation

CLC Number:

R512.91

Li Zhen, Wu Hao, Zhang Tong. Analysis of T cell activation in early HIV-infected individuals from MSM population[J]. Journal of Capital Medical University, 2014, 35(1): 92-95.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2014.01.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2014/V35/I1/92

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