Related research of HTERC gene in cervical intraepithelial neapalsia after the treatment

doi:10.3969/j.issn.1006-7795.2015.06.020

Abstract

Abstract: Objective To explore the monitoring value of human telomerase RNA component(HTERC) gene in cervical intraepithelial neapalsia(CIN) after the treatment. Methods Totally eight-three patients confirmed as cervical intraepithelial neapalsia were chosen. Those patients were examined with thin prep cytologic test(TCT), high risk-human papillomavirus(HR-HPV) detection, multi-point biopsy and HTERC gene preoperative. Then we examined TCT, HPV, HTERC gene and colposcopy biopsy at the time of 6 months and 1 year follow-up. Results 1 With the histological lesion degree increasing, HTERC gene positive expression rate increased, and the increased difference is statistically significant. 2 Half year after the treatment, we discovered that the cytology, high-risk type HPV positive rate and positive HTERC gene detection rate(HTERC gene positive rate was 0% after the treatment), were significantly reduced compared with preoperative, and it suggested that the surgery could effectively reduce the degree of cervical lesions, high-risk type HPV positive rate and positive rate of HTERC gene. 3 Comparing those tests, we found that the TCT had the highest positive predictive value, the HR-HPV had the highest sensitivity and negative predictive value, and the HTERC had the highest specificity. Conclusion When patients have HR-HPV infection, and especially have the CIN, it will help predict the direction of development of the disease with the HTERC gene detects added.

Key words: human telomerase RNA component, cervical intraepithelial neapalsia, fluorescence in situ hybridizatiom, human papillomavirus, thin prep cytologic test

CLC Number:

Zhou Lihong, He Xihong, Long Yan, Lin Li. Related research of HTERC gene in cervical intraepithelial neapalsia after the treatment[J]. Journal of Capital Medical University, 2015, 36(6): 946-952.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2015.06.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2015/V36/I6/946

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