Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion

doi:10.3969/j.issn.1006-7795.2016.05.025

Journal of Capital Medical University ›› 2016, Vol. 37 ›› Issue (5): 688-692.doi: 10.3969/j.issn.1006-7795.2016.05.025

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Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion

Li Jiayin¹, Li Yanglu², Ruan Xiangyan², Li Yulin¹, Liu Minru³

1. The Key Laboratory of Pathobiology, Ministry of Education, College of Basic Medical Sciences, Jinlin University, Changchun 130012, China;
2. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
3. Teaching and Research Section of Department of Gynecology, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China

Received:2016-09-09 Online:2016-10-21 Published:2016-10-19
Supported by:
This study was supported by Capital Characteristic Clinic Project of China(Z161100000516143); Beijing Capital Foundation for Medical Science Development and Research(2016-2-2113); Beijing Municipality Health Technology High-Level Talent (2014-2-016).

Abstract

Abstract: Objective To observe the effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion (RSA). Methods Seventy-six RSA patients were divided into study group (n=45) and control group(n=31) randomly. The patients in the study group were treated with estradiolhemihydrates patches combined with Zi Gui Nv Zhen capsules, and the those in control group were treated with estradiolhemihydratepatches alone. Both groups were treated for 3 cycles. The endometrium thickness and type, the pulsation index (PI) and resistance index (RI) of uterine helicine artery blood flow after ovulation were monitored, serum estradiol and progesterone were detected in luteal phase. The clinical pregnancy rate and live birth rate were followed up. Results After treatment for 3 cycles, the study group obtained more type A endometrium, lower PI and RI significantly, and the endometrium thickness in study group increases more than that in control group significantly. After one year, the study group obtained higher clinical pregnancy rate and live birth rate significantly. Conclusion Estradiolhemihydratepatches combined with Zi Gui Nv Zhen capsule can improve the endometrial blood flow and corpus luteum function, optimize the type of endometrium in RSA patients, improve the endometrium receptivity, and increase their pregnancy rate and live birth rate. It indicates that Estradiolhemihydratepatches combined with Zi Gui Nv Zhen capsule provide new treatment method for RSA patients.

Key words: recurrent spontaneous abortion, Zi Gui Nv Zhen capsule, endometrium receptivity, clinical pregnancy rate, livebirth rate

CLC Number:

R714.21

Li Jiayin, Li Yanglu, Ruan Xiangyan, Li Yulin, Liu Minru. Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion[J]. Journal of Capital Medical University, 2016, 37(5): 688-692.

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Effects of Zi Gui Nv Zhen capsule on recurrent spontaneous abortion

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