Therapeutic effect of placenta-derived mesenchymal stem cells on recurrent spontaneous abortion

doi:10.3969/j.issn.1006-7795.2019.03.020

Abstract

Abstract: Objective To investigate the therapeutic effect of placenta-derived mesenchymal stem cells (PMSC) on recurrent spontaneous abortion (RSA).Methods Female CBA/J mice were mated with male DBA/2 mice in 2:1 to construct RSA models (n=12). The RSA models were randomly divided into the experimental group and control group, six mice in each group. Mice in the experimental group were injected with PMSC and mice in the control groups were injected with PBS. The mice were killed on day 13.5 of pregnancy,and we calculated the abortion rate,and the weight of embryonic rat and placenta. The placental tissues were also detected to identify the Laminin and Cytokeratin 8 by immunohistochemistry.Results The embryo resorption rates in the experimental group were under the control group (P<0.05),and the weight of embryonic rat and placenta in the experimental group were higher than that of the control group (P<0.05).Conclusion The embryo resorption rate in RSA mice is decreased after injected with PMCS,providing new ideas for the treatment of recurrent spontaneous abortion.

Key words: placenta-derived mesenchymal stem cells, recurrent spontaneous abortion, therapy, animal research

CLC Number:

R714.21

Zhou Ping, Liu Cheng, Wang Qiushi, Zhu Zhiqing, Cao Guangming, Liu Chongdong, Zhang Zhenyu. Therapeutic effect of placenta-derived mesenchymal stem cells on recurrent spontaneous abortion[J]. Journal of Capital Medical University, 2019, 40(3): 434-438.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.03.020

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I3/434

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