Journal of Capital Medical University ›› 2017, Vol. 38 ›› Issue (4): 492-497.doi: 10.3969/j.issn.1006-7795.2017.04.002

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Clinical predictive value of anti-Müllerian hormone and inhibin B in polycystic ovary syndrome

Wang Husheng1, Ruan Xiangyan1,2, Li Xue1, Zhao Yue1, Li Yanglu1, Gu Muqing1, Du Juan1, Song Jinghua1, Jin Fengyu1, Alfred O. Mueck1,2   

  1. 1. Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100026, China;
    2. Section of Endocrinology and Menopause, Department of Women's Health, University of Tubingen, Tubingen D-72076, Germany
  • Received:2017-06-05 Online:2017-07-21 Published:2017-07-20
  • Supported by:
    This study was supported by Capital Characteristic Clinic Project of China(Z161100000516143); Beijing Capital Foundation for Medical Science Development and Research(2016-2-2113); Clinical Technique Innovation Project of Beijing Municipal Administration of Hospitals(XMLX201710); Beijing Municipality Health Technology High-level Talent(2014-2-016);Foreign Technical and Administrative Talent Introduction Project in 2017, State Administration of Foreign Experts Affairs of China(20171100004)

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Abstract: Objective The present study aimed to investigate the effects of inhibin B (INHB), anti-Mullerian hormone (AMH) and various endocrine indicators in patients with polycystic ovary syndrome (PCOS) and control group, and to explore the clinical predictive value of INHB and AMH and compare the characteristics of endocrine indexes in two groups.Methods A total of 567 PCOS patients and 53 normal subjects as a control group were enrolled. Fasting blood samples for hormones ［anti-Müllerian hormone(AMH), inhibinB(INHB), follicle-stimulating hormone (FSH),luteinizing hormone (LH), estradiol (E2) and testosterone (T)］ were measured. Results The AMH concentration, LH, T and body mass index (BMI) in PCOS group were significantly higher than those in control group. The E2 and FSH/LH were lower than those in control group, and the difference was statistically significant (P<0.05). The concentration of INHB in PCOS group was higher than that in control group, FSH level was lower than that in control group, and there was no significant difference between the two groups (P> 0.05). Receiver operating characteristic (ROC) curve analysis of serum AMH and INHB in prediction of PCOS showed that the area under the ROC curve (AUC) value of the serum AMH level was 0.814, with a cut-off value of 4.84 μg/L. The sensitivity and specificity were 84.48% and 69.81%, respectively. The AUC value of serum INHB was 0.575, with a cut-off value of 70.8 ng/L, and the sensitivity and specificity were 53.97% and 67.92%, respectively. AMH and INHB combined prediction (Parallel Test) polycystic ovary syndrome sensitivity was 90.29%, specificity was 54.92%. Conclusion The cut-off value of AMH predicted PCOS was 4.84 μg/L, and the cut-off value of INHB predicted PCOS was 70.8 ng/L. The sensitivity of combined detection (Parallel Test)of AMH and INHB was higher than that of AMH single test. The prediction of PCOS will have a very important guiding significance.

Key words: polycystic ovary syndrome, anti-Müllerian hormone, inhibin B, combined detection

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