Abstract: Objective Healthy young college students as the research objects, based on the observation of dietary fat fluid of palm oil (PO), cocoa butter (CO), soybean oil (SO) of human serum complement component C3, C4 and tumor necrosis factor-α(TNF-α), interleukin-10 (IL-10) and the activity of normal T cell expressed and secreted regulatory proteins (RANTES) levels. Methods To meet inclusion and exclusion criteria of healthy young college students as subjects, according to body mass index (BMI), students can be divided into 3 groups at random, respectively is palm oil, cocoa butter, soybean oil group, each group of 31 people, a total of 93 people, intake with grease 12 weeks, respectively. Respectively, at the beginning of the experiment and the end of experiment detected objects composition of serum C3, C4 and cytokine TNF-α, IL-10, chemokine RANTES levels. Results Before and after the experiment of each group, the serum complement C3 and C4 levels were all decreased, and the difference was statistically significant (P<0.05). The serum TNF-α level was significantly decreased in palm oil group and soybean oil group (P<0.05). Serum IL-10 level was significantly increased in soybean oil group (P<0.05). There was no significant change in serum RANTES level in the three groups (P>0.05). Before and after the experiment, there was no significant difference in serum complement composition, cytoinflammatory cytokines and activity regulation protein levels in the three groups (P>0.05). Conclusion Palm oil, cocoa butter and soybean oil may reduce the inflammation of the body, especially the effect of soybean oil group is more significant.

Key words: dietary oil, complement component, inflammatory cytokine, chemokine