Journal of Capital Medical University ›› 2013, Vol. 34 ›› Issue (6): 795-798.doi: 10.3969/j.issn.1006-7795.2013.06.003

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Expression of CC family chemokines in the tissue of chronic rhinosinusitis in Northern China

LI Ying1, WANG Xiangdong1,2, WANG Hong1, BO Mingyu2, SONG Beibei2, FAN Erzhong1, ZHANG Luo1,2   

  1. 1. Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China;
    2. Beijing Institute of Otorhinolaryngology, Key Laboratory of Otorhinolaryngology Head and Neck Surgery, Ministry of Education, Beijing Key Laboratory of Nasal Diseases, Beijing 100005, China
  • Received:2013-10-08 Online:2013-12-21 Published:2013-12-13
  • Supported by:

    This study was supported by the National Science Foundation for Distinguished Young Scholars(81025007);Beijing Key Laboratory of Nasal Diseases(Z121107009212032).

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Abstract:

Objective To evaluate the expression and roles of chemokines in chronic rhinosinusitis without nasal polyps(CRSsNP) and with nasal polyps(CRSwNP) in Northern China. Methods Ninety-four cases of NP tissue, 33 cases of sinus mucosa of CRSsNP and 24 cases of control were enrolled in the present study. ELISA was used to measure CCL2(MCP-1), CCL3(MIP-1a), CCL4(MIP-1b), CCL5(RANTES) and Eotaxin in homogenization of nasal mucosa and polyp tissue. Results CCL2(MCP-1), CCL3(MIP-1a), CCL4(MIP-1b) and Eotaxin in NP tissue were significantly higher than those in CRSsNP and control tissue. CCL4(MIP-1b) and Eotaxin in eosinophilic NP tissue was significantly higher than those in neutrophilic NP. No significant difference of CCL5(RANTES) was found among the above groups. Conclusion Chemokine CCL2(MCP-1), CCL3(MIP-1a), CCL4(MIP-1b) and Eotaxin may play important roles in the pathogenesis of nasal polyps.

Key words: chronic rhinosinusitis, nasal polyp, chemokines

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