Expression of cell junctions in the tissue of chronic rhinosinusitis

doi:10.3969/j.issn.1006-7795.2013.06.004

Abstract

Abstract:

Objective To evaluate the expression of cell junctions in the tissue of chronic rhinosinusitis and their roles in barrier function of epithelium. Methods Eosinophilic nasal polyps and non-eosinophilic nasal polyps of chronic rhinosinusitis with nasal polyps(CRSwNP), sinus mucosa of chronic rhinosinusitis without nasal polyps(CRSsNP) and control mucosa were enrolled in this study. Each group included 15 cases. Zonulae occludens(ZO-1), E-cadherin and desmoglein-1(dsg-1) were stained by immunohistochemistry. Results The expression of ZO-1 in eosinophilic nasal polyps group were significantly less than that in other groups(P<0.05). The expressions of E-cadherin in nasal polyps and CRSsNP group were significantly more than that in control group(P<0.05). The expressions of dsg-1 in nasal polyps groups and CRSsNP group were significantly less than that in control group(P<0.05), while dsg-1 of nasal polyps groups were significantly less than that of CRSsNP group(P<0.05). Conclusion The changes of cell junctions may play important roles in the pathogenesis of chronic rhinosinusitis.

Key words: chronic rhinosinusitis, cell junction, epithelial barrier function

CLC Number:

R765.4

Li Ying, Fan Erzhong, Bo Mingyu, Wang Xiangdong, Zhang Luo. Expression of cell junctions in the tissue of chronic rhinosinusitis[J]. Journal of Capital Medical University, 2013, 34(6): 799-804.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2013.06.004

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2013/V34/I6/799

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