Analysis for the relationship between interleukin-21 and tissue IgE in recurrent nasal polyps

doi:10.3969/j.issn.1006-7795.2020.02.009

Abstract

Abstract: Objective To investigate the relationship between tissue total IgE and postoperative recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) and to further analyze the associated immunological molecules contributing to IgE production. Methods We retrospectively enrolled 73 CRSwNP patients and 24 healthy volunteers as a control group, and compared the clinical characteristics and the levels of tissue IgE, interleukin-4, IL-21 and CD40 ligand of the patients after endoscopic sinus surgery for 3 years. Sequentially, we analyzed the correlation between IgE and these immunological molecules. Results The presence of asthma comorbidity was significantly more frequent in recurrent CRSwNPs than non-recurrent group (30.3% vs 10%). The IgE levels in recurrent group[257.40(143.00-776.05)KU/L] was also significantly higher than that in non-recurrent group[98.89(43.56-255.20)KU/L], while the levels of CD40L, IL-4 and IL-21 showed no differences between the two groups. Among the 73 CRSwNPs (regardless of recurrence or non-recurrence), IL-21 significantly related to CD40L (r=0.440, P<0.001) and IgE(r=0.290,P=0.01). IL-21 significantly related to IgE in the recurrent group while not in non-recurrent group. CD40L and IL-4 showed no relationship with IgE neither in recurrent nor non-recurrent group. Conclusion Increased levels of IgE in nasal polyps related to the recurrence of CRSwNPs. IL-21, not CD40L and IL-4, might contribute to the IgE production in recurrent CRSwNPs.

Key words: chronic rhinosinusitis with nasal polyps, CD40L, IgE, interleukin-21, recurrence

CLC Number:

R765.4

Du Kun, Zheng Ming, Wang Xiangdong, Zhang Luo. Analysis for the relationship between interleukin-21 and tissue IgE in recurrent nasal polyps[J]. Journal of Capital Medical University, 2020, 41(2): 194-199.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2020.02.009

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2020/V41/I2/194

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