Occurrence and prognosis value of Snail and Claudin-3 expression in hepatocelluar carcinoma

doi:10.3969/j.issn.1006-7795.2018.03.015

Abstract

Abstract: Objective This study aimed to investigate the relationship between the expression of Claudin-3 or Snail and the clinical pathology and prognosis in the hepatocellular carcinoma (HCC) patients by detecting the expression of Claudin-3 and Snail in the HCC and liver cancer-adjacent tissues.Methods Snail and Claudin-3 were detected in cases of 60 liver cancer-adjacent tissues and 82 cases of HCC by using immunohistochemical technique. The postoperative prognostic factors were assessed by univariate Kaplan-Meier analysis and a multivariate Cox proportional hazard model.Results Snail positive expression was 69.47% in HCC and was significantly higher than liver cancer-adjacent tissues (P=0.001). Claudin-3 proteins positive expression were 47.61%in HCC and were significantly lower than liver cancer-adjacent tissue (P=0.002). The expression of Snail and Claudin-3 was negatively correlated (r=-0.430, P<0.01). Snail positive expression in HCC was significantly higher than liver cancer-adjacent tissues, and the difference was statistically significant in microvascular invasion and stages of pathology tumor lymph node metastasis (P<0.05). Multivariate analysis by using Cox regression model identified that Snail and Claudin-3 were independent prognostic factors of HCC (P<0.05).Conclusion The correlation between the Snail or Claudin-3 and the occurrence and invasion in HCC were exhibited. The combined detection of Snail and Claudin-3 protein in HCC patients might be an important pathological and prognosis biomarker in HCC patients.

Key words: hepatocellular carcinoma, Snail, Claudin-3

CLC Number:

R730.5

Shen Yanjun, Chen Jinglong, Che Juanjuan, Wang Jing, Cao Bangwei. Occurrence and prognosis value of Snail and Claudin-3 expression in hepatocelluar carcinoma[J]. Journal of Capital Medical University, 2018, 39(3): 393-397.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2018.03.015

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2018/V39/I3/393

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