Effect of Jinkui Shenqi Pill on serum nerve growth factor in depression patients with kidney deficiency and liver stagnation

doi:10.3969/j.issn.1006-7795.2019.02.013

Abstract

Abstract: Objective To investigate the effect of Jinkui Shenqi Pill on serum nerve growth factor (NGF) in depression patients with kidney deficiency and liver stagnation. Methods The patients were divided into the trail group (30 cases) and control group (30 cases) by random number table method. The trail group were treated with Jinkui Shenqi Pill combined with escitalopram oxalate, one dose a day given in the morning and evening. The control group were treated with escitalopram oxalate at a dose 20 mg/d alone. The treatment course was 8 weeks. The Montgomery-Asberg-Rating Scale (MADRS) and traditional Chinese medicine (TCM) symptoms scale were measured before and at the end of weeks 2, 4 and 8, and the serum NGF levels were also recorded. Results There was no significant difference in MADRS and TCM symptoms scores before treatment between the two groups (P>0.05). The evaluation interval (2, 4, and 8 weeks) was taken as the intra-group factor and the group (trail group and control group) as the inter-group factor. By repeated measurement of variance analysis, the intra-group factor (MADRS) independent variable effect was significant[F_(2,58)=301.367,P=0.000], and the interaction between intra-group and inter-group factors was significant[F_(2,58)=4.022,P=0.008] while inter-group factor independent variable effect was significant[F_(2,58)=9.658,P=0.003];the intra-group factor (TCM symptoms) independent variable effect was significant[F_(2,58)=355.130,P=0.000], and the interaction between intra-group and inter-group factors was not significant[F_(2,58)=0.970,P=0.374],and the interaction between intra-group and inter-group factors was significant[F_(2,58)=5.336,P=0.024].It suggested that the therapeutic efficiency of the trail group is better than that of the control group. The levels of NGF before treatment in both groups were equivalent in general,with no significant difference (P>0.05).After the treatment, the NGF level in the trail group was high than that in the control group with significant difference (P<0.05). Pearson correlation analysis showed that the difference of NGF levels before and after treatment in the trail group was positively correlated with the difference of kidney deficiency score (r=0.481,P=0.007) and the difference of liver stagnation score (r=0.370,P=0.044).Conclusion Jinkui Shenqi Pills can effectively improve the symptoms of depression patients with kidney deficiency and liver depression.Compared to the patients using escitalopram oxalate alone, the serum NGF concentration in the combinatorial group increased significantly.

Key words: Jinkui Shenqi Pill, depression, kidney deficiency and liver stagnation, nerve growth factor

CLC Number:

R749.4

Li Miao, Wang Qunsong, Yuan Guozhen. Effect of Jinkui Shenqi Pill on serum nerve growth factor in depression patients with kidney deficiency and liver stagnation[J]. Journal of Capital Medical University, 2019, 40(2): 220-225.

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URL: https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/10.3969/j.issn.1006-7795.2019.02.013

https://journal03.magtech.org.cn/Jweb_sdykdxxb/EN/Y2019/V40/I2/220

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