Abstract: Parallel detections of RF, IK and HBsAg-specific CIC were performed in different types of patients with chronic HB. Our study disclosed that the incidence of RF, IK in HBAC and CAH was remarkably higher than that in CPH, and this result was consistent with the difference of the incidence of HBsAg-CIC among these types of disease. In addition, in HBAC and CAH the incidence of RF and IK clo-sely followed by HBsAg-CIC was higher and their keeping time was also longer than those in CPH. Dynamic observations showed that there existed a consistent changes among HBsAg-CIC, RF, and the level of the comple. mentconsumed by soluble CIC in patient's sera, and a close relationship with the aggravation of hepatic func-tion impairment. The data suggested that RF and IK might be harmful pathogenetic factors to the host in chronic HBV infection.