Abstract:

Acute experimental hepatitis induced by carbon. tetrachloride (CCl₄) is one of the classical animal models used in laboratory. The present paper showed that low and moderate doses of cantharidin prevented effectively the hepatic damage and increased in serum level of GPT in these models. Whereas extra-high doses of cantharidin might also lead to hepatic damage and increase in GPT level, but such changes were much less milder than that induced by CCl₄.