Abstract: Electro-acupuncture stimulation of different intensity was bilaterallyapplied to rabbits'“Huantiao”points.The changes in concentrationof 5-hydroxytryptamine (5-HT),5-hydroxyindole acetic acid (5-HIAA),dopamine (DA)and norepinephrine (NE)were measured by means offluorometry.Concentrations of the four monoamines were found toincrease significantly in varying extent under strong stimulation;therewere an obvious rising of 5-HT and 5-HIAA but an obvious decreasein DA and NE concentration in case of weak stimulation and weak plusstrong stimulation.All these changes were statistieally very significantThe results indicate that the neural processes caused by the threedifferent means may not be completely the same and alterations inmonoamine concentrations can be evoked by these stimulations.Thissuggests that there is certain correlation between these chemicals andelectro-acupuncturing as well as noxious stimulation.Further study ofthe correlation mechanism is needed.