Abstract: Sodium Fulvate had anti-inflammatory,hemostatic and anti-cancereffects and was used clinically,The toxicity and side effect of SodiumFulvate were studied in the present paper.Through stimulation test on rabbit,hypersensitivity test onguinea-pig,acute toxicity test on mouse and subacute toxicity test onrabbit,Sodium Fulvate showed neither stimulation nor hypersensitiveeffect.and the acute toxicity of Sodium Fulvate was low,the ip LD50was 1728±110.57mg/kg.when Sodium Fulvate with low concentration (<0.8%)and lowdosage (approximately 10 times of therapeutic dose)was administeredinto the rabbit,no toxicity and side effect were observed.