Journal of Capital Medical University ›› 1987, Vol. 8 ›› Issue (1): 23-26.

• 论著 • Previous Articles     Next Articles

Inducing Role of Oxymatrine on the Hepatic Microsomal Drug-metabolism Enzyme in Mice

Yuan Cai, Lü Shiqi, Yao Xian   

  1. Department of Pharmcaology
  • Received:1900-01-01 Revised:1900-01-01 Online:1987-01-15 Published:1987-01-15

PDF

203

Abstract: The effect of Oxymatrine(OMT),isolated from Sophora flavescens Ait,on the hepatic microsomal drug-metabolism enzyme have been investigated.It was found that the content of cytochrome P-450 (P-450),the ethylmorphine N-demethylase,the p-nitroanisole O-demethylase and the benzo(a)pyrene hydroxylase activities were significantly increased in OMT(100mg/kg)-pretreated mice.The proliferation of smooth endoplamic reticulum of liver cells was also stimulated by OMT.The results indicated that Oxymatrine is a inducer of P-450.

Key words: Cytochrome P-450, Oxymatrine, Drug-metabolism enzyme