Abstract: The antioxidant Dmainly containing N-phenyl-2-naphthyl-amine was a pollutant of the rubber industry,In this paper the influences of antioxidant Don drug-metabolizing enzymes of the liver and the lungs of the rat were studied.The results indicated that the antioxi-dant Ddecreased the mouse sleep time induced by pentobarbital sodium and increased the organ coefficient,the content of the hepatic microso- mal cytochrome P-450,the activities of the NADPH-Cytochrome Creductase of the hepatic microsome,GSH S-transferase of the liver S₉ and benzopyrene hydroxylase,ethylmorphine demethylase,p-nitroani- sole demethylase of the liver and the lungs.The antioxidant Dcould stimulate proliferation of smooth endoplasmatic reticulum of the liver cells and the lung cells.

Key words: antioxidant D, cytochrome P-450, drug metabolizing enzymes, mixed function oxidase, GSH S-transferase