The Measurement of Plasma Angiotensin Ⅱ by HPLCRIA and the Observation on the Inhibition of the Plasma Angiotensin Ⅱ Generation by Captopril

Journal of Capital Medical University ›› 1987, Vol. 8 ›› Issue (3): 204-208.

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The Measurement of Plasma Angiotensin Ⅱ by HPLCRIA and the Observation on the Inhibition of the Plasma Angiotensin Ⅱ Generation by Captopril

Yu Zhongyuan

Cardiovasular Research Lab Xuanwu Hospital Capital Institute of Medicine

Received:1900-01-01 Revised:1900-01-01 Online:1987-07-15 Published:1987-07-15

Abstract

Abstract: The plasma angiotensin II(ATII)has been separated by Sep-Pak C¹³and purified by HPLC then measured by RIA.25 mg of Captopril was administred orally to 8 patients with essential hypertension. The significant change of Plasma ATII started from 10 minutes after administration of Captopril.Plasma ATII and MAP both reached the lowest level at 60 minutes after Captopril,such response between plasma renin activity(PRA)and MAP was not observed.

Key words: AngiotensinⅡ, Captopril, HPLC, RIA

Yu Zhongyuan. The Measurement of Plasma Angiotensin Ⅱ by HPLCRIA and the Observation on the Inhibition of the Plasma Angiotensin Ⅱ Generation by Captopril[J]. Journal of Capital Medical University, 1987, 8(3): 204-208.

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The Measurement of Plasma Angiotensin Ⅱ by HPLCRIA and the Observation on the Inhibition of the Plasma Angiotensin Ⅱ Generation by Captopril

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