Abstract: 72 adult male rats were divided into 2 groups, i. e. control group and D-galactosamine administration group. The thyroids were removed at different time intervals (1, 2, 3, 5, 7 and 10 days) after injecting D-galactosamine, and then stained with histochemical and immunohistochemical PAP method. The findings were as follows. On the first to 3 rd day after injecting D-galactosamine, the lumen of the follicles were enlarged, follicular epithelial cells became short, the amount of colloid deposits were increased. Except the ATPase, the reac-tions of RNA, ACP, SDH, G6PDH and PO Were Weaker than those of the control group. Both of the amount of colloid droplets and the Immunoreaction substances of T₃ and T₄ declined. Although on the 5 th day, all of the indexes increased, they returned to normal level after 7 days. The results were suggested that the changes of the thyroid follicles following injecting D-galactosamine were closely related to the iniury and the regeneration process of liver.

Key words: D-galactosamine, thyroid follicle, rat