Abstract: Standard microelectrode technique was used to investigate the effects of sodium ferulate on action potential of ventricular muscle of quinea-pig. After 30-min-perfusion with three concentrations of sodium ferulate (0.1mg/mL, 0.2mg/mL and 0.4mg/mL) seperatly, the altitude of action potential and the duration of 20% repolarization showed no change, but the duration of 90% repolarization and the effective refractary period increased significantly. Morevere, the duration of 50% repolarization of action poten- tial could increase markedly at the concentrations of 0.1mg/mL and 0.2mg/mL.

Key words: sodium ferulate, ventricular muscle, action potential