Abstract: Fresh human endometrium in the follicular and luteal phases of the menstrual cycle and wall decidual tissues at 6-11 weeks of gestation were collected by suction curettage. Content of the different kindes of neurotransmitters and neuropeptides in the endometrial and decidual tissues were tested using HPLC technique and RIA, respectively. It was found that the contents of neurotransmitters and neuropeptides in the decidua were very abandant, and DA, DOPAC. β- EP and LH-RH of them in the decidua appeared significantly higher than those in the endometrium (P<0.05). The contents of DA and DOPAC in the decidua increased gradually with the prolongation of the gestation weeks (p<0.05). On the contrary,β-EP and LH-RH showed decrease (p<0.05). These preliminary results suggest that the decidua synthesizes not only β-EP, LH-RH, but also neurotransmitters.

Key words: follicular phase, luteal phase, wall decidua, early pregnancy, enurotransmitters, neuropiptides