Abstract: The effects of adenosine on action potential of guinea pig atrium at different concentrations and temperatures were observed with microelectrode technique, At 21℃, the effects of adrenargic receptors blockers as phenoxybenzamine phentolamine and propranolol on adenosine etion were researched. hTe results suggest that the effects of adenosine aon action potential of at rium muscle is concentration and temperature-dependent. Propranolol partly but phentolamine and phenoxybenzamine completely block adenosine effects. It is suggested that adenosine and catecholamine share certain common receptors but perform different functions respectively.

Key words: adenosine, action potential, catecholamine receptor, phentolamine, phenoxyben zamine, propranolol