Abstract: The variation of DA, NE, 5-HT and 5-HIAA in CSF was observed on 10 patients suffering from Parkinson's disease after auto-transplantation of adrenal mellula. It was found that while the patients’ objective symptoms were relieved, the contents of DA in (SF increased significantly at the 2nd, 4th, 6th and 8th week, excepling for the first week after operation. The results suggest that the operation may raise the content of DA in CSF, which is thought to be involved in the pathogenesis of Parkinson’s disease. There are no considerable alterations in the contents of NE, 5-HT and 5-HIAA, however, it doesn’t imply that there is no relationship between these substances and Parkinson’s disease.

Key words: Parkinson’s, monoamines, intracephajic transplantation