Abstract: Ficol-Hypaque separated peripheral bloo dmononuclear cells were analysed by indirect immunofluorescence assay with ortho monoclonal antibodies to T cells (OKT₃⁺), helper cells (OKT₄⁺) and suppressor cytotoxic cells (OKT₈⁺). 20 normal subjects and 23 patients with acute polyradiculoneuritis (AP) wore studied, The percentages of OKT₃⁺ and OKT₄⁺ cells were similar in the 2 groups, but the percentages of OKT₈⁺ cells was reduced to 18.96±4.24 compared with 22.28±3.15 in the the normal subjects (p <0.05). The ratio of OKT₄⁺/OKT₈⁺ cells was correspondingly increased to 2.38±0.55, compared with 1.97±0.20 in the normal subjects. These changes fell towards normal with the passage of time. The result suggests that AP might be an autoimmunity disease with cell immunity disorders.

Key words: acute polyradiculoneuritis, human T lymphocyte, monoclonal antibodies, indirect immunofluorescence assay