Journal of Capital Medical University ›› 1994, Vol. 15 ›› Issue (3): 191-193.

• 论著 • Previous Articles     Next Articles

Induction of Micronuclei in Mice Treated with Extracts of Particulates from Liquefied Petroleum Gas(LPG)Combustion

Yin Xuejun1, Li Yongshun1, Kong Xianghuan1, Liu Junzhuo2   

  1. 1. Departmentof Environmental Health, Capital Institute of Medicine;2. Department of Environmental Health, Beijing Medical University
  • Received:1993-06-07 Revised:1900-01-01 Online:1994-07-15 Published:1994-07-15

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Abstract: Methylene chloride extracts of particulates from LPG combustion appliance were studied in micronucleus test in mice.The test was carried out with Kunming mice treated with the extracts at 100,200 and 400 mg/kg(ip,twice).A significant dose-dependent increase in MNPCE was clearly observed in all dose groups compared to that of the control(P<0.01).The extracts also had a marked cytotoxic effect on bone marrow as indicated by a significant reduction in PCE/NCE ratio with the dose(P<0.05).Therefore,it was considered that the extracts might be clastogen or spindle poison that was mutagenic in vivo and might be potential carcinogenic.

Key words: liquefied petroleum gas, particulate, micronucleus test, indoor air pollution

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