Abstract: The purpose of the present study is to observe the therapeutic effects of calcitonin generelated peptide on arrhythmias caused by ouabain or aconitine in rats.3 minutes afterthe appearance of arrhythmia induced by ouabain(11 mg/ kg,iv)or aconitine(60 μg/kg, iv),the animals were divided into two groups at random which were infused with normalsaline(as control)or CGRP(40 μg/kg),respectively.In ouabain model,only one survived,while the other five(83%)died.In CGRP group,survival rate is 100%(7/7).In aconitine model,only four survived(4/6),one animal returned to stable sinus rhythm, with mean persistent time of 2.17±4.84 min.In CGRP group,survival rate is 100 %(7/7),five returned to stable sinus rhythm with mean persistent time of 20.93±13.24 min ,compared with control group,P<0.05.The results show that,the therapeutic effects of CGRP on arrhythmias caused by ouabain or aconitine are obvious.

Key words: calcitonin gene related peptide, arrhythmias, ouabain, aconitine, rat