Abstract: Rabbits were immunized with a mixture of dihydrostreptomycin,streptomycin sulfate,pure streptomycin and Freund's complete adjuvant. Serum samples were collected at differ ent time after immunization, followed by a level detection of antistreptomycin products in each sample. Our result showed that most animals could produce antibodies against strepto mycin. Our experiments also testified the presence of the immunogenicity of streptomycin. So far by now, aminoglycoside antibiotics such as streptomycin and gentamycin have already been proved to be semiantigens. When they are combined with amines of protein or polypep tide in vivo, complete antigens are formed, and antigen-antibody reactions take place. So we presume that a further study of the relationship between the ototoxicity of the antibiotics and immunology will be much meaningful to the study of ototoxic pathogenesis.

Key words: streptomycin, immunogenicity, ototoxicity