Ornithine Decarboxylase Inhibitor Reduces Brain Damage of Focal Ischemia in Cats

Abstract

Abstract: Ornithine decarboxylase(ODC), the rate limiting enzyme of polyamine metabolism,is felt to be important in the generation of ischemic brain edema and infarction.We measured Evens blue staining,regional blood flow(rCBF) and specific gravity of brain tissue following focal ischemia in cat middle cerebral artery occlusion model.Pretretment with ODC inhibitor α-difluoromethylornithine(DFMO) decresed Evens blue staining from 29.6% to 17.2% (P<0.01) and also reduced specific gravity from 1.028 to 1.016 (P<0.01).The rCBF increased by a maximum of 394% as compared with control group.These data suggest that polyamine production and ODC activity play a significant role in the development of ischemic edenia.

Key words: cerebral ischemia, polyamine, ornithine decarboxylase

CLC Number:

Q463

Hu Ying'an;Hou Minglun;Yang Haipuig. Ornithine Decarboxylase Inhibitor Reduces Brain Damage of Focal Ischemia in Cats[J]. Journal of Capital Medical University, 1995, 16(4): 253-255.

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Ornithine Decarboxylase Inhibitor Reduces Brain Damage of Focal Ischemia in Cats

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