Abstract: The mutagenicity of urine from humans exposed to the combustion products of liquefied petroleum gas(LPG)was detected with Salmonella typhimurium TA98 and its new derivatives YG1021 and YG1024.The samples showed evident mutagenicity in thepresence of both rat liver S₉ and β-glucuronidase.The mutagenicity in YG1024 was significantly higher than that in TA98.The mutagenicity in YG1021,however,was similar to TA98 under the same conditions.This suggests that the mutagenic compounds presented in the urine samples are mainly aromatic amino compounds as glucuronide conjugates.The results also demonstrate that YG1024 is more sensitive than TA98 in detecting the mutagenicity of these samples.

Key words: liquefied petroleum gas, combustion product, urine mutagenicity, Ames test