Abstract: Fifty cases of patients with acute severe infection (24 cases with DIC and 26 cases with out DIC) were studied and prothrombin time (PT), activated partial thromboplastin time (APTT),fibrinogen(Fg) concentration,platelet (PLT) count,anti-thrombin Ⅲ (AT-Ⅲ) activity,plasminogen (PLG) activity, α₂-antiplasmin (α₂AP) activity,D-Dimer concentration in plasma were examined.The results suggested that DIC was the important causes for the pathogenesis and development of MSOF.The single detection data of Fg had no more diagnostic importance in infectious DIC, PT,APTT,Plt, AT-Ⅲ, PLG, α₂-AP, D-Dimer were all helpfull laboratory parameters for diagnosing DIC.The diagnostic rate of DIC by using a single parameter was less than 80 percent, the diagnostic rate of DIC by using combined multiple parameters was more than 90 percent.

Key words: acute severe infection, disseminated intravascular coagulation, laboratory diagnosis, coagulation system, fibrinolytic system