Journal of Capital Medical University ›› 1996, Vol. 17 ›› Issue (3): 189-192.

• 论著 • Previous Articles     Next Articles

Synthesis and Antimicrobial Activities of Some Novel 1, 3, 5-Thiadiazine-2-Thiones

Chen Gaiqing1, Zou Jingxun1, Zhu Ying1, Li Yulan2   

  1. 1. Department of Chemistry, Capital University of Medical Sciences;2. Department of Microbiology, Capital University of Medical Sciences
  • Received:1900-01-01 Revised:1995-05-11 Online:1996-07-15 Published:1996-07-15

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Abstract: A number of novel 1, 3, 5-thiadiazine-2-thiones have been synthysized using benzylamine reacted with potassium hydroxide,carbon disulphide, formaldehyde and various amino acids.The structures of compounds have been elucidated by UV, IR, 1H-NMR and elementary analysis.The activity of the compounds against 6 bacterias and 2 fungus was tested in vitro.All compounds were found to be potent against the gramnegative and less potent against the gram-positive and fungus.

Key words: antimicrobial activity, thiadiazinethiones, antimicrobial drug

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