The Effect of Calcitonin Gene Related Peptide on Arrhythmia Caused by Acontine in Heterotopic Heart Transplant Rats

Journal of Capital Medical University ›› 1996, Vol. 17 ›› Issue (4): 277-279.

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The Effect of Calcitonin Gene Related Peptide on Arrhythmia Caused by Acontine in Heterotopic Heart Transplant Rats

Wang Rong¹, Li Shuang¹, Ye Cuifei², Sheng Shuli¹, Yue Xiaohui²

1. Polypeptide Laboratory, Beijing Xuanwu Hospital , Affiliate of Capital University of Medical Sciences;2. Transplantation Immunology Laboratory

Received:1995-12-11 Revised:1900-01-01 Online:1996-10-15 Published:1996-10-15

Abstract

Abstract: Calcitonin gene related peptide(CGRP) is a most potent vasodilator.It plays an important role on arrhythmia.The purpose of this study was to observe the effects of CGRP on arrhythmia caused by aconitine in heterotopic heart transplant rats.The results showed : ①Both aceptor heart and transplanted heart had very weak reaction to CGRP.This suggested that the transplant heart has less CGRP receptors than normal heart.②CGRP can induce the appearance of P wave of electrocardiogram in one transplanted heart,this involved that CGRP may have a stimulation to sinus.

Key words: calcitonin gene related peptide, aconitine, heterotopic heart transplant, arRhythmia

CLC Number:

R654.2

Wang Rong;Li Shuang;Ye Cuifei;Sheng Shuli;Yue Xiaohui. The Effect of Calcitonin Gene Related Peptide on Arrhythmia Caused by Acontine in Heterotopic Heart Transplant Rats[J]. Journal of Capital Medical University, 1996, 17(4): 277-279.

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The Effect of Calcitonin Gene Related Peptide on Arrhythmia Caused by Acontine in Heterotopic Heart Transplant Rats

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