Abstract: In order to make a primate model for Parkinsonizm,13 monkeys(Macaque)were ipsilaterally injected through the common carotid artery by 1-methyl-4-pheny-1,2,3,6-tetrahydropyridine(MPTP). Among them, the extrenal carotid artery in 6 monkeys was clipped before the injection. All animals with symptoms showed to have a decrease of density in the area of the substantia nigra on the image of MRI after 1 month of injection. In addition, the tyrosine hydroxylase immunoreactive neurons in the ventral midbrain area on the injection side were decreased in these monkeys. The results showed that ipsilateral injection of MPTP into the common carotid artery with a temporary blockage of the external carotid artery was a good technique for producing the primate model for Parkinsonizm.

Key words: MPTP, carotid artery monkey, Parkinsonizm