Journal of Capital Medical University ›› 1998, Vol. 19 ›› Issue (1): 13-18.

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A Long Term Toxicity Test of Mycobacterial Polysaccharides

Wu Ping1, Su Yilan1, Chen Zhenliang1, Liu Zhen1, Zhang Jie1, Li Juan1, Jiang Zhicheng1, Zhao Wenming2, Chen Ren2   

  1. 1. Department of Industrial Health, Capital University of Medical Scienses;2. Department of Immunology, Capital University of Medical Sciences
  • Received:1997-04-25 Revised:1900-01-01 Online:1998-01-15 Published:1998-01-15

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Abstract: long term toxicity test of Mycobacterial polysaccharides(MPS)was carried out. Experimental groups with three different doses(1.5、7.5 and 15.0 μg/kg)of MPS were compared with the control in the parameters of growth ratio, coefficieny of food utilization, routine and specific tests of blood, OW/BW ratio and pathological examinations. Results showed no significant statistical differences between the experimental animals and controls. This study shows that MPS with such test doses has no adverse effect to the rats denoting that MPS can be used for long term treatment.

Key words: Mycobacterial polysaccharide, immunomodulator, long term toxicity test

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