Abstract: Using fully automated immunoassay system Imx, the serum alpha fetoprotein(AFP)levels in patients with primary hepatocellular carcinoma(PHC)and chronic active hepatitis(CAH)were quantitatively determined. Results: In 75% of patients with PHC, the serum AFP levels were unnormal. In 11 patients, before and after operation, the serum AFP levels were observed dynamically. The serum AFP levels were elevated in 21.8% of 110 patients with CAH. In 13 of 15 cases, the serum AFP levels were from 14.27 nmol/L to normal. In another 2 cases, the serum AFP levels were persistently high, denoting a poor prognoses. Changes in contents of AFP coincided with changes of disease course and prognosis of PHC and CAH.

Key words: primary hepatocellular carcinoma, chronic active hepatitis, immunoassay system Imx