Abstract: Repetitive hypoxia method was used to study the adaptation of mice to intermittent hypoxia and the effect of gangliosides. The activity of GSHpx was decreased(P<0.01), not only in blood but also in brain. Under acute repetitive hypoxia for 4 times, the activity of GSHpx in brain was increased(P<0.05)as compared with that under the hypoxia for one time. At that time, the gangliosides in the membrane of brain cell were decreased(P<0.01). It showed that Gls and the activity of GSHpx were interrelated. The contents of norepinephrine in brain were lower than the controls(P<0.01). The results indicated that the system of β receptor adenyl cyclase was not injured by acute and repetitive hypoxia.

Key words: acute hypoxia, repetitive hypoxia, gangliosides, glutathione peroxidase, blood sugar