Abstract:

Forty adult Kunming rats were used and divided into four groups, i.e. normal control group and three experimental 2-ethoxyethanol(EE)-induced groups. The results of pathomorphological observation of testes in EE groups showed: Primary spermatocytes degenerated and necrosed, spermatids differentiation ceased, the number of mature spermatozoon diminished. The epithe lium cells had degenerated and the ductal wall of epididymis became thinner. The stroma cells of the testis proliferated. The above lessions were aggrevated as the dose of EE increased. The fact indicated that EE had pathological effects on testis and epididymis. It was recommended that regular examination of the function of spermatosome should performed on those who professionally exposed to EE, and proper protective action should be adopted.

Key words: 2-ethoxyethanol, rat, testis, epididymis, pathomorphology