Abstract:

Rat was used as the hypoxia model by being kept in the normobaric hypoxia chamber. The lung sections were stained with routine HE, VG and immunohistochemical methods. Some specimens were examined by electromicroscope. Results showed that the remodeling of the pulmonary vascular structure under chronic hypoxia included: ① significant proliferation of the adventitial collagen fiber in pulmonary arteries. ②hypertrophy of the medial coat of peripheral muscular arterioles and ③ muscularization of the nonvascular arterioles in the alveolar septa.

Key words: chronic hypoxia, remodeling of vascular structure, pathologic changes