Angiotensin converting Enzyme Genotype Distribution in Patients with Hypertrophic Cardiomyopathy

Journal of Capital Medical University ›› 2000, Vol. 21 ›› Issue (2): 112-114.

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Angiotensin converting Enzyme Genotype Distribution in Patients with Hypertrophic Cardiomyopathy

Gao Mingming¹, Xiao Bai², Hu Dayi¹, Zhu Zhangling², Xu Zhimin¹, Shao Wei², Zhou Yan², Zhou Ju², Liu Jingzhong²

Beijing Red Cross Chaoyang Hospital, Affiliate of Capital University of Medical Sciences

Received:1999-04-19 Revised:1900-01-01 Online:2000-04-15 Published:2000-04-15

Abstract

Abstract: To investigate differences in the angiotensin converting enzyme(ACE) genotype between patients with hypertrophic cardiomyopathy(HCM) and hypertensive patients with LVH(HH) in China, polymerase chain reaction technique was used to study the ACE gene insertion/deletion polymorphism in 40 HCM patients, 50 HH patients and 61 random controls. The results suggested that the frequencies of D allele were higher in the HCM group (0.513) than in the C gourp (0.344, P<0.05) and the HH group (0.360, P< 0.05), and that the II genotype were lower in the HCM group (0.300) than in the C group (0.508, P< 0.05). This research indicated that ACE D allele was more common in patients with HCM compared with patients with HH.

Key words: angiotensin converting enzyme gene, hypertrophic cardiomyopathy, hypertension

CLC Number:

R544.1

Gao Mingming;Xiao Bai;Hu Dayi;Zhu Zhangling;Xu Zhimin;Shao Wei;Zhou Yan;Zhou Ju;Liu Jingzhong. Angiotensin converting Enzyme Genotype Distribution in Patients with Hypertrophic Cardiomyopathy[J]. Journal of Capital Medical University, 2000, 21(2): 112-114.

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Angiotensin converting Enzyme Genotype Distribution in Patients with Hypertrophic Cardiomyopathy

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