Abstract: The study evaluated the effectiveness and safety of using the leukocyte reduction filter in the stem cell transplantation unit of the department of hematology. The filters were used in 11 patients who were treated with peripheral blood stem cell transplantation. The effectiveness of the leukocyte reduction, the recovery of the red cell or pletlet were measured. The occurance of TA-GVHD and the other reaction of transfusion were observed. By using the filters, white cells could be controlled within 10 5, and TA-GVHD could be efficiently avoided. The reaction rate of transfusion was reduced from 37.8%(20/53)which did not use the filters in general ward to 15.0%(6/40, P<0.005). Leukocyte reduction filter could be safely used in the stem cell transplantation of the hema tological department.

Key words: leukocyte reduction filter, transfusion, stem cell transplantation