Abstract: To evaluate the efficacy of local intramuscular injections of three different doses of botulinum Atoxin (B-TXA) in the management of the spasm of cerebral palsy. Method: 120 cases of children with cerebral palsy were divided into three average groups: group 1, group 2 and group 3. Three different doses of BTX-A (group 1, 1 U/kg; group 2, 2 U/kg; group 3, 3 U/kg) were administered. The spastic muscles were identified by palpitation. The effect of treatment was evaluated by PRS method. The different efficacy between each group was calculated by analysis of variance. The tolerance to BTX-A and the side effects were also assessed. Result: Reduction on spasm of muscles in all patients (100%) became apparent after injection (P<0.01). There is significant differences when the three different doses group was compared one by one (see table). Larger quantity of BTX-A(2 U/kg, 3 U/kg) is more effective than that of less quantities. No major side effects occurred. Larger quantity of BTX Atreating cerebral palsy is more effective than that of smaller quantity. It is safe when the dosages are in a suitable range (≤6 U/kg).

Key words: botulinum-A toxin, cerebral palsy, treatment