Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (1): 9-11.

• 论著·基础研究 • Previous Articles Next Articles

Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

Zhang Liping¹, Jing Xuefang¹, Zhang Haiyan², Ping Guoling¹, Shen Haizhong¹, Li W eihong², Zhang Hongchun¹, Li Yuying¹

1. Department of Immunology, Capital University of Medical Sciences;2. Department of Microbiology, Gapital University of Medical Sciences

Received:2003-06-23 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

Abstract

Abstract: The goal was to evaluate the effect of Streptococcal HlpA on IL-6 level in muri ne serum. Serum levels of IL-6 production were measured by means of 7TD1 IL-6 dependent cell line. The IL-6 levels in murine serum induced with Streptococcal HlpA were time and concentration dependent in vivo. There was a synergistic res ponse on the IL-6 level in murine serum induced by the mixture of HlpA and LTA, compared to HlpA alone. On the contrary, anti-HlpA and heparin could restrain serum levels of IL-6 production induced by intravenous injection o f HlpA. It means that Streptococcal HlpA can increase serum levels of IL-6 pr oduction induced by intravenous injection of HlpA. There was significant synergi sm on it in mice vivo after HlpA and LTA were injected together.

Key words: Streptococcus, BALB/C mice, inter lukin-6

CLC Number:

R378.1⁺2

Zhang Liping;Jing Xuefang;Zhang Haiyan;Ping Guoling;Shen Haizhong;Li W eihong;Zhang Hongchun;Li Yuying. Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum[J]. Journal of Capital Medical University, 2004, 25(1): 9-11.

[1]	Li Dong, Zhang Shuchen, Shi Yanli, Li Xueqing, Lu Binghuai. Antibiotic resistance and serotype distribution of group B Streptococci in pregnant women in Beijing [J]. Journal of Capital Medical University, 2018, 39(4): 591-595.
[2]	Zhang Shuchen, Wang Shan, Zhu Fengxia, Shi Yanli, Li Dong, Lu Binghuai. Evaluation of the performance of chromogenic agar in the screening group B streptococcus from pregnant women [J]. Journal of Capital Medical University, 2016, 37(5): 680-683.
[3]	WU Wen-qi;CONG Xu-zhen;YIN Ai-hong;HU Jia;ZHAI Fang-li;LI Shen-tao. Expression, purification and characterization of ribose 5-phosphate isomerase A from Streptococcus mutans [J]. Journal of Capital Medical University, 2012, 33(2): 227-232.
[4]	Li Yanqin;Wang Yan;Cao Ning;Ping Guoling;Li Weihong;Zhang Liping. Effects of Streptococcal Protein on the Human Hepatocellular Carcinoma Bel-7402 Cells and Human Normal Liver Cells [J]. Journal of Capital Medical University, 2008, 29(5): 605-609.
[5]	Yang Ming;Yang Yonghong;Dmitriev Alexander;Shen Adong;Tong Yuejuan;Fan Xunmei. The Relation of Insertion Elements IS861 and IS1548 to Genotype and Phenotype of Group B Streptococci [J]. Journal of Capital Medical University, 2007, 28(4): 471-475.
[6]	Chen Yi;Huang Xinghua. The Relationship between Cytokine and Group B Streptococcus Subclinical Infection in Pregnancy [J]. Journal of Capital Medical University, 2005, 26(5): 612-615.
[7]	Wang Yonghong;Tong Yuejuan;Yu Sangjie;Yang Yonghong. Resistance of Streptococcus Pneumoniae to β-lactams Macrolides and Fluoroquinolone among Children [J]. Journal of Capital Medical University, 2005, 26(5): 517-520.
[8]	Zhang Liping;Zhang Hongchun;Jing Xuefang;Shen Haizhong;Ping Guoling;Li Yuying. Effect of Human PMN on the Streptococcal Histone-Like Protein Release [J]. Journal of Capital Medical University, 2003, 24(3): 228-230.
[9]	Shen Haizhong;Zhang Liping;Ping Guoling;Zhang Hongchun;Jing Xuefang;Li Yuying;Li Yulan;Li Weihong;Zhang Haiyan. Streptococcal Histone-Like Protein Induces Murine Peritoneal MΦ to Produce IL-6 [J]. Journal of Capital Medical University, 2003, 24(1): 11-13.
[10]	Zhang Zhenting;Zhao Chen;Yuan Yushu. The Relationship between the Degree of Roughness of the Denture Surface and the Adherence of Streptococcus mutans in Vitro [J]. Journal of Capital Medical University, 2000, 21(1): 59-60.
[11]	Zhao Lian. Effects of Vaginal Group B StreptococcalCarrier State at Term on Mother infant [J]. Journal of Capital Medical University, 1999, 20(4): 285-286.
[12]	Li Ling;Lu Guowei;An Yangyuan. Effects of Acute Repeated Hypoxia on Hypoxia Tolerance of BALB/C Mice [J]. Journal of Capital Medical University, 1995, 16(4): 249-252.
[13]	Liu Ke;Gao Tionxiang. Studies on the Effects of the Secreta of Human Colonic a Denocarcinoma HT-29 Cell Line on the Mouse Fibroblasts [J]. Journal of Capital Medical University, 1989, 10(4): 268-273.

Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 13

Recommended Articles

Metrics

Comments