Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

Journal of Capital Medical University ›› 2004, Vol. 25 ›› Issue (1): 9-11.

• 论著·基础研究 • Previous Articles Next Articles

Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

Zhang Liping¹, Jing Xuefang¹, Zhang Haiyan², Ping Guoling¹, Shen Haizhong¹, Li W eihong², Zhang Hongchun¹, Li Yuying¹

1. Department of Immunology, Capital University of Medical Sciences;2. Department of Microbiology, Gapital University of Medical Sciences

Received:2003-06-23 Revised:1900-01-01 Online:2004-01-15 Published:2004-01-15

Abstract

Abstract: The goal was to evaluate the effect of Streptococcal HlpA on IL-6 level in muri ne serum. Serum levels of IL-6 production were measured by means of 7TD1 IL-6 dependent cell line. The IL-6 levels in murine serum induced with Streptococcal HlpA were time and concentration dependent in vivo. There was a synergistic res ponse on the IL-6 level in murine serum induced by the mixture of HlpA and LTA, compared to HlpA alone. On the contrary, anti-HlpA and heparin could restrain serum levels of IL-6 production induced by intravenous injection o f HlpA. It means that Streptococcal HlpA can increase serum levels of IL-6 pr oduction induced by intravenous injection of HlpA. There was significant synergi sm on it in mice vivo after HlpA and LTA were injected together.

Key words: Streptococcus, BALB/C mice, inter lukin-6

CLC Number:

R378.1⁺2

Zhang Liping;Jing Xuefang;Zhang Haiyan;Ping Guoling;Shen Haizhong;Li W eihong;Zhang Hongchun;Li Yuying. Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum[J]. Journal of Capital Medical University, 2004, 25(1): 9-11.

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Effect of Streptococcal Histone-Like Protein on IL-6 Level in Murine Serum

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