Abstract:

Objective The aim was to evaluate the feasibility of propofol and lidocaine used for neurosurgical surgery and to find out the proper dose. Methods Sixty patients were randomly allocated into four groups with different doses of lidocaine and propofol. BPand HR were controlled by nicardipine and esomolol. BIS,SEF and the hemodynamic parameters were measured continuously; the dose of nicardipine and esomolol, the recovery time and the side-effects were recorded. Results 1) The BIS and SEF values of four groups were all decreased significantly after induction. The BIS values of group Cwere lower while those of group Dwere higher than those of group A. 2) The total dose of esomolol in group Cand Dwere 43.2% and 54.4% respectively which was less than that of group A. The total dose of nicardipine in group Cand Dwere 43.4% and 54.3% respectively which was less than that of group A. Conclusion 1) Lidocaine have the power to strengthen the sedition of propofol. 2) Lidocine has the dose-dependent effect of analgesia. 3) Propofol and lidocaine are suitable for neurosurgical surgery and the proper dose is propofol 5 mg/kg and lidocaine 2.5 mg/kg.

Key words: lidocaine, propofol, protection of brain function